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KMID : 0960920020010020095
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.95 ~ p.100
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Event-Related Evoked Potentials in Non-Demented Patients with Non-Insulin Dependant Diabetes Mellitus
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Youn Young-Chul
Ha Sam-Yeol
Shin Dong-Sun
Han Seung-Ho
Kwon Oh-Sang
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Abstract
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Background: Cognitive impairment has been recognized as a possible complication of diabetes mellitus (DM). It is well known that event-related potentials (ERPs) and Hopkins Verbal Learing Test (HVLT) are clinical tools in the evaluation of the patients who suffer from disorders of cognition. The present study was designed to investigate the effect of diabetes mellitus and its complications on the ERPs and HVLT.
Methods: A cross sectional comparative study of the 51 normal controls and the 40 non-demented NIDDM patients who had no neurologic deficits was performed. The study consisted of a neurologic examination, Short form-Samsung Dementia Questionnaire, brain CT, ERPs, HVLT, nerve conduction study, fundus examination and biochemical study.
Results: The P300 latencies of the DM patients and the normal control groups were well correlated with age. Compared with controls, the P300 latencies of the patients were significantly prolonged. In NIDDM patients, prolonged P300 latencies were not associated with neuropathy but with retinopathy (p<0.05). P300 latencies of NIDDM were correlated with immediate free recall of HVLT. There were no significant differences in scores of HVLT components between NIDDM and normal control group.
Conclusions: NIDDM patients without overt dementia or other CNS disorders may have a subtle cerebral malfunction, which can be detected by ERPs but not by verbal learning test. Therefore ERPs might be a useful tool to evaluate subtle cognitive dysfunction. It is suggested that the factors responsible for genesis of this cerebral malfunction are not influenced by short-term metabolic dysfunction and may be different from those responsible for the DM neuropathy.
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KEYWORD
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Non-insulin dependant diabetes mellitus, Event related evoked potentials, P300, Hopkins verbal learing test
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